Personalised Cancer Medicine Flashcards 2022
Indications determined by the organ of origin
GIST
Standard
Recommended
Currently not recommended
- CD 117/c-kit
- CD34
- Number of mitosis/50 large fields
- KIT and PDGFR mutations
- DOG1*
- BRAF, SDHB, NTRK**
- NF1
- RAS
- FGFR
* CD117 negative
** GIST wild type
** GIST wild type
The Standard category is based on current treatment indications with approved funding by the Spanish National Health System.
The Recommended category is based on currentrecommendations by EMEA and FDA.
The Recommended category is based on currentrecommendations by EMEA and FDA.
References:
1. Martin-Broto J, Martinez-Marín V, Serrano et al. Gastrointestinal stromal tumors (GISTs): SEAP-SEOM consensus on pathologic and molecular diagnosis. Clin Transl Oncol. 2017 May;19(5):536-545. doi: 10.1007/s12094-016-1581-2.
