Personalised Cancer Medicine Flashcards 2022

Indications determined by the organ of origin
Melanoma
Melanoma

Standard

Recommended

Currently not recommended
  • BRAF
  • KIT*
  • NRAS
  • GNAQ/GNA11
  • PTEN
  • MITF
  • CDKN2A
  • MHC-II
  • Tumor mutational burden
* in mucosal or acral melanoma or melanoma associated with sunlight
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The Standard category is based on current treatment indications with approved funding by the Spanish National Health System.
The Recommended category is based on currentrecommendations by EMEA and FDA.

References:

1. Martín-Algarra S, Fernández-Figueras MT, López-Martín JA, at al; Spanish Society of Pathology; Spanish Society of Medical Oncology. Guidelines for biomarker testing in metastatic melanoma: a National Consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology. Clin Transl Oncol. 2014 Apr;16(4):362-73. doi: 10.1007/s12094-013-1090-5.

2. Scherrer E, Rau R, Lorenzi M, Shui I, Townson S, Larkin J. Systematic literature review for the association of biomarkers with efficacy of anti-PD-1 inhibitors in advanced melanoma. Future Oncol. 2021 Mar 30. doi: 10.2217/fon-2021-0154.

3. Mao L, Dai J, Cao Y, et al. Palbociclib in advanced acral melanoma with genetic aberrations in the cyclin-dependent kinase 4 pathway. Eur J Cancer. 2021 Mar 23;148:297-306. doi: 10.1016/j.ejca.2021.02.021.